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KMID : 0357920040380010060
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Korean Journal of Pathology
2004 Volume.38 No. 1 p.60 ~ p.63
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Squamous Cell Carcinoma Developed in Nevus Sebaceus - A Case Report -
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Choi Hyun-Joo
Yoo Jin-Young
Maeng Lee-So
Kang Seok-Jin
Kang Chang-Suk
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Abstract
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We report a case of squamous cell carcinoma developed within the nevus sebaceus (NS) and review the literature. An 82-year-old woman presented with a 3-month history of pain within the lifelong skin lesion on her right cheek. Examination revealed a 1.0×1.0 cm poorly marginated, slightly raised yellow-brown nodule. Microscopically, the skin nodule revealed the typical findings of NS. Squamous cell carcinoma developed contiguously within the keratin-filled infundibulocyst of NS disconnected from the epidermis. We suggest that squamous cell carcinoma is derived from the embryonal stratum germinativum de-differentiated from the primary epithelial germ cells in the infundibulocyst of NS. Most secondary carcinomas associated with NS grow slowly over a period of years. In contrast, squamous cell carcinoma developed in NS often grow rapidly with aggressive behavior. Thus, the accurate pathologic diagnosis is necessary.
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